- A multicenter study of interobserver variability in pathologic diagnosis of papillary breast lesions on core needle biopsy with WHO classification
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Hye Ju Kang, Sun Young Kwon, Ahrong Kim, Woo Gyeong Kim, Eun Kyung Kim, Ae Ree Kim, Chungyeul Kim, Soo Kee Min, So Young Park, Sun Hee Sung, Hye Kyoung Yoon, Ahwon Lee, Ji Shin Lee, Hyang Im Lee, Ho Chang Lee, Sung Chul Lim, Sun Young Jun, Min Jung Jung, Chang Won Jung, Soo Youn Cho, Eun Yoon Cho, Hye Jeong Choi, So Yeon Park, Jee Yeon Kim, In Ae Park, Youngmee Kwon
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J Pathol Transl Med. 2021;55(6):380-387. Published online October 6, 2021
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DOI: https://doi.org/10.4132/jptm.2021.07.29
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Abstract
PDFSupplementary Material
- Background
Papillary breast lesions (PBLs) comprise diverse entities from benign and atypical lesions to malignant tumors. Although PBLs are characterized by a papillary growth pattern, it is challenging to achieve high diagnostic accuracy and reproducibility. Thus, we investigated the diagnostic reproducibility of PBLs in core needle biopsy (CNB) specimens with World Health Organization (WHO) classification.
Methods Diagnostic reproducibility was assessed using interobserver variability (kappa value, κ) and agreement rate in the pathologic diagnosis of 60 PBL cases on CNB among 20 breast pathologists affiliated with 20 medical institutions in Korea. This analysis was performed using hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for cytokeratin 5 (CK5) and p63. The pathologic diagnosis of PBLs was based on WHO classification, which was used to establish simple classifications (4-tier, 3-tier, and 2-tier).
Results On WHO classification, H&E staining exhibited ‘fair agreement’ (κ = 0.21) with a 47.0% agreement rate. Simple classifications presented improvement in interobserver variability and agreement rate. IHC staining increased the kappa value and agreement rate in all the classifications. Despite IHC staining, the encapsulated/solid papillary carcinoma (EPC/SPC) subgroup (κ = 0.16) exhibited lower agreement compared to the non-EPC/SPC subgroup (κ = 0.35) with WHO classification, which was similar to the results of any other classification systems.
Conclusions Although the use of IHC staining for CK5 and p63 increased the diagnostic agreement of PBLs in CNB specimens, WHO classification exhibited a higher discordance rate compared to any other classifications. Therefore, this result warrants further intensive consensus studies to improve the diagnostic reproducibility of PBLs with WHO classification.
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- Invasive papillary carcinoma of the breast
Shijing Wang, Qingfu Zhang, Xiaoyun Mao Frontiers in Oncology.2024;[Epub] CrossRef - Encapsulated papillary carcinoma of the breast: A single institution experience
Liang Xu, Qixin Mao, Qiuming Liu, Yufeng Gao, Lihua Luo, Chungen Guo, Wei Qu, Ningning Yan, Yali Cao Oncology Letters.2023;[Epub] CrossRef - High-risk and selected benign breast lesions diagnosed on core needle biopsy: Evidence for and against immediate surgical excision
Aparna Harbhajanka, Hannah L. Gilmore, Benjamin C. Calhoun Modern Pathology.2022; 35(11): 1500. CrossRef
- Standardized pathology report for breast cancer
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Soo Youn Cho, So Yeon Park, Young Kyung Bae, Jee Yeon Kim, Eun Kyung Kim, Woo Gyeong Kim, Youngmee Kwon, Ahwon Lee, Hee Jin Lee, Ji Shin Lee, Jee Young Park, Gyungyub Gong, Hye Kyoung Yoon
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J Pathol Transl Med. 2021;55(1):1-15. Published online January 11, 2021
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DOI: https://doi.org/10.4132/jptm.2020.11.20
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7,967
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Abstract
PDFSupplementary Material
- Given the recent advances in management and understanding of breast cancer, a standardized pathology report reflecting these changes is critical. To meet this need, the Breast Pathology Study Group of the Korean Society of Pathologists has developed a standardized pathology reporting format for breast cancer, consisting of ‘standard data elements,’ ‘conditional data elements,’ and a biomarker report form. The ‘standard data elements’ consist of the basic pathologic features used for prognostication, while other factors related to prognosis or diagnosis are described in the ‘conditional data elements.’ In addition to standard data elements, all recommended issues are also presented. We expect that this standardized pathology report for breast cancer will improve diagnostic concordance and communication between pathologists and clinicians, as well as between pathologists inter-institutionally.
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- Residual pure intralymphatic carcinoma component only (lymphovascular tumor emboli without invasive carcinoma) after neoadjuvant chemotherapy is associated with poor outcome: Not pathologic complete response
Hyunwoo Lee, Yunjeong Jang, Yoon Ah Cho, Eun Yoon Cho Human Pathology.2024; 145: 1. CrossRef - Sentinel lymph node biopsy in patients with ductal carcinomain situ: systematic review and meta-analysis
Matthew G. Davey, Colm O’Flaherty, Eoin F. Cleere, Aoife Nohilly, James Phelan, Evan Ronane, Aoife J. Lowery, Michael J. Kerin BJS Open.2022;[Epub] CrossRef
- Clinicopathologic characteristics of HER2-positive pure mucinous carcinoma of the breast
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Yunjeong Jang, Hera Jung, Han-Na Kim, Youjeong Seo, Emad Alsharif, Seok Jin Nam, Seok Won Kim, Jeong Eon Lee, Yeon Hee Park, Eun Yoon Cho, Soo Youn Cho
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J Pathol Transl Med. 2020;54(1):95-102. Published online November 13, 2019
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DOI: https://doi.org/10.4132/jptm.2019.10.24
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6,864
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Abstract
PDF
- Background
Pure mucinous carcinoma (PMC) is a rare type of breast cancer, estimated to represent 2% of invasive breast cancer. PMC is typically positive for estrogen receptors (ER) and progesterone receptors (PR) and negative for human epidermal growth factor receptor 2 (HER2). The clinicopathologic characteristics of HER2-positive PMC have not been investigated.
Methods Pathology archives were searched for PMC diagnosed from January 1999 to April 2018. Clinicopathologic data and microscopic findings were reviewed and compared between HER2-positive PMC and HER2-negative PMC. We also analyzed the differences in disease-free survival (DFS) and overall survival according to clinicopathologic parameters including HER2 status in overall PMC cases.
Results There were 21 HER2-positive cases (4.8%) in 438 PMCs. The average tumor size of HER2-positive PMC was 32.21 mm (± 26.55). Lymph node metastasis was present in seven cases. Compared to HER2-negative PMC, HER2-positive PMC presented with a more advanced T category (p < .001), more frequent lymph node metastasis (p = .009), and a higher nuclear and histologic grade (p < .001). Microscopically, signet ring cells were frequently observed in HER2-positive PMC (p < .001), whereas a micropapillary pattern was more frequent in HER2-negative PMC (p = .012). HER2-positive PMC was more frequently negative for ER (33.3% vs. 1.2%) and PR (28.6% vs. 7.2%) than HER2-negative PMC and showed a high Ki-67 labeling index. During follow-up, distant metastasis and recurrence developed in three HER2-positive PMC patients. Multivariate analysis revealed that only HER2-positivity and lymph node status were significantly associated with DFS.
Conclusions Our results suggest that HER2-positive PMC is a more aggressive subgroup of PMC. HER2 positivity should be considered for adequate management of PMC.
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- Comprehensive Immunohistochemical Analysis of Mesonephric Marker Expression in Low-grade Endometrial Endometrioid Carcinoma
Yurimi Lee, Sangjoon Choi, Hyun-Soo Kim International Journal of Gynecological Pathology.2024; 43(3): 221. CrossRef - Pure Mucinous Carcinoma of the Breast: Radiologic-Pathologic Correlation
Cherie M Kuzmiak, Benjamin C Calhoun Journal of Breast Imaging.2023;[Epub] CrossRef - Role of circ-FOXO3 and miR-23a in radiosensitivity of breast cancer
Elahe Abdollahi, Hossein Mozdarani, Behrooz Z. Alizadeh Breast Cancer.2023; 30(5): 714. CrossRef - On Ultrasonographic Features of Mucinous Carcinoma with Micropapillary Pattern
Wei-Sen Yang, Yang Li, Ya Gao Breast Cancer: Targets and Therapy.2023; Volume 15: 473. CrossRef - Spectrum of Mucin-containing Lesions of the Breast: Multimodality Imaging Review with Pathologic Correlation
Janice N. Thai, Melinda F. Lerwill, Shinn-Huey S. Chou RadioGraphics.2023;[Epub] CrossRef - Mesonephric-like Adenocarcinoma of the Ovary: Clinicopathological and Molecular Characteristics
Hyun Hee Koh, Eunhyang Park, Hyun-Soo Kim Diagnostics.2022; 12(2): 326. CrossRef - Alveolar Soft Part Sarcoma of the Uterus: Clinicopathological and Molecular Characteristics
Yurimi Lee, Kiyong Na, Ha Young Woo, Hyun-Soo Kim Diagnostics.2022; 12(5): 1102. CrossRef - Metastasis of the Mucionous adenocarcinoma of breast to the mandibular gingiva: Rare case report
Ivana Mijatov, Aleksandra Fejsa Levakov, Aleksandar Spasić, Jelena Nikolić, Saša Mijatov Medicine.2022; 101(38): e30732. CrossRef - Endometrioid Carcinomas of the Ovaries and Endometrium Involving Endocervical Polyps: Comprehensive Clinicopathological Analyses
Jihee Sohn, Yurimi Lee, Hyun-Soo Kim Diagnostics.2022; 12(10): 2339. CrossRef - Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report with Emphasis on the Immunostaining and the Identification of Splice Site TP53 Mutation
Sangjoon Choi, Yoon Yang Jung, Hyun-Soo Kim Diagnostics.2021; 11(4): 717. CrossRef - HER2 positive mucinous carcinoma of breast with micropapillary features: Report of a case and review of literature
Dinesh Chandra Doval, Rupal Tripathi, Sunil Pasricha, Pankaj Goyal, Chaturbhuj Agrawal, Anurag Mehta Human Pathology: Case Reports.2021; 25: 200531. CrossRef - Carcinoma mucosecretor de mama HER2-positivo, un caso clínico
A.M. González Aranda, E. Martínez Gómez, A. Santana Costa, F. Arnanz Velasco, M.H. González de Diego, A. Zapico Goñi Clínica e Investigación en Ginecología y Obstetricia.2021; 48(4): 100685. CrossRef - Clinicopathologic features of unexpectedly HER2 positive breast carcinomas: An institutional experience
Carissa LaBoy, Kalliopi P. Siziopikou, Lauren Rosen, Luis Z. Blanco, Jennifer L. Pincus Pathology - Research and Practice.2021; 222: 153441. CrossRef - Mesonephric-like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-like Adenocarcinoma
Sujin Park, Go Eun Bae, Jiyoung Kim, Hyun-Soo Kim Diagnostics.2021; 11(8): 1450. CrossRef - Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Immunohistochemical Analyses Using Markers for Mesonephric, Endometrioid and Serous Tumors
Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun-Soo Kim Diagnostics.2021; 11(11): 2042. CrossRef
- TFE3-Expressing Perivascular Epithelioid Cell Tumor of the Breast
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Hyunjin Kim, Jimin Kim, Se Kyung Lee, Eun Yoon Cho, Soo Youn Cho
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J Pathol Transl Med. 2019;53(1):62-65. Published online October 1, 2018
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DOI: https://doi.org/10.4132/jptm.2018.08.30
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6,562
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- Perivascular epithelioid cell tumor (PEComa) is a very rare mesenchymal tumor with a distinctive morphology and immunophenotype. PEComas usually harbor TSC2 alterations, although TFE3 translocations, which occur in MiT family translocation renal cell carcinoma and alveolar soft part sarcoma, are also possible. We recently experienced a case of PEComa with TFE3 expression arising in the breast. An 18-year-old female patient presented with a right breast mass. Histologically, the tumor consisted of epithelioid cells with alveolar structure and showed a diffuse strong expression of HMB45 and TFE3. TSC2 was preserved. Melan A and smooth muscle actin were negative. To our knowledge, this is the first Korean case of PEComa of the breast that intriguingly presented with TFE3 expression.
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- Malignant lung PEComa (clear cell tumor): rare case report and literature review
Marcos Adriano Garcia Campos, Lucas Fernandes Vasques, Rafael Goulart de Medeiros, Érico Murilo Monteiro Cutrim, Ana Júlia Favarin, Sarah Rebecca Machado Silva, Gyl Eanes Barros Silva, Marcelo Padovani de Toledo Moraes, Mariana Lopes Zanatta, Diego Aparec Frontiers in Oncology.2023;[Epub] CrossRef - Cathepsin K: A Versatile Potential Biomarker and Therapeutic Target for Various Cancers
Die Qian, Lisha He, Qing Zhang, Wenqing Li, Dandan Tang, Chunjie Wu, Fei Yang, Ke Li, Hong Zhang Current Oncology.2022; 29(8): 5963. CrossRef - Endometrioid Carcinomas of the Ovaries and Endometrium Involving Endocervical Polyps: Comprehensive Clinicopathological Analyses
Jihee Sohn, Yurimi Lee, Hyun-Soo Kim Diagnostics.2022; 12(10): 2339. CrossRef - Serous Carcinoma of the Endometrium with Mesonephric-Like Differentiation Initially Misdiagnosed as Uterine Mesonephric-Like Adenocarcinoma: A Case Report with Emphasis on the Immunostaining and the Identification of Splice Site TP53 Mutation
Sangjoon Choi, Yoon Yang Jung, Hyun-Soo Kim Diagnostics.2021; 11(4): 717. CrossRef - Mesonephric-like Differentiation of Endometrial Endometrioid Carcinoma: Clinicopathological and Molecular Characteristics Distinct from Those of Uterine Mesonephric-like Adenocarcinoma
Sujin Park, Go Eun Bae, Jiyoung Kim, Hyun-Soo Kim Diagnostics.2021; 11(8): 1450. CrossRef - Mesonephric-like Adenocarcinoma of the Uterine Corpus: Comprehensive Immunohistochemical Analyses Using Markers for Mesonephric, Endometrioid and Serous Tumors
Hyunjin Kim, Kiyong Na, Go Eun Bae, Hyun-Soo Kim Diagnostics.2021; 11(11): 2042. CrossRef - Invasive Lobular Carcinoma With Extensive Clear Cells: A Pitfall in Diagnosis
Mark H. Kavesh, Daniel Sanchez, Jaya Ruth Asirvatham International Journal of Surgical Pathology.2020; 28(2): 169. CrossRef - Glycogen-rich Clear Cell Carcinoma of the Breast: A Comprehensive Review
Semir Vranic, Faruk Skenderi, Vanesa Beslagic, Zoran Gatalica Applied Immunohistochemistry & Molecular Morphology.2020; 28(9): 655. CrossRef - TFE3-expressing primary perivascular epithelioid cell tumor of the Lymph node mimicking nodal relapse of rectal cancer: A case report
Jongmin Park, An Na Seo International Journal of Surgery Case Reports.2019; 59: 46. CrossRef
- The Prognostic Impact of Synchronous Ipsilateral Multiple Breast Cancer: Survival Outcomes according to the Eighth American Joint Committee on Cancer Staging and Molecular Subtype
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Jinah Chu, Hyunsik Bae, Youjeong Seo, Soo Youn Cho, Seok-Hyung Kim, Eun Yoon Cho
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J Pathol Transl Med. 2018;52(6):396-403. Published online October 23, 2018
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DOI: https://doi.org/10.4132/jptm.2018.10.03
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Abstract
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- Background
In the current American Joint Committee on Cancer staging system of breast cancer, only tumor size determines T-category regardless of whether the tumor is single or multiple. This study evaluated if tumor multiplicity has prognostic value and can be used to subclassify breast cancer.
Methods We included 5,758 patients with invasive breast cancer who underwent surgery at Samsung Medical Center, Seoul, Korea, from 1995 to 2012.
Results Patients were divided into two groups according to multiplicity (single, n = 4,744; multiple, n = 1,014). Statistically significant differences in lymph node involvement and lymphatic invasion were found between the two groups (p < .001). Patients with multiple masses tended to have luminal A molecular subtype (p < .001). On Kaplan-Meier survival analysis, patients with multiple masses had significantly poorer disease-free survival (DFS) (p = .016). The prognostic significance of multiplicity was seen in patients with anatomic staging group I and prognostic staging group IA (p = .019 and p = .032, respectively). When targeting patients with T1-2 N0 M0, hormone receptor–positive, and human epidermal growth factor receptor 2 (HER2)–negative cancer, Kaplan-Meier survival analysis also revealed significantly reduced DFS with multiple cancer (p = .031). The multivariate analysis indicated that multiplicity was independently correlated with worse DFS (hazard ratio, 1.23; 95% confidence interval, 1.03 to 1.47; p = .025). The results of this study indicate that tumor multiplicity is frequently found in luminal A subtype, is associated with frequent lymph node metastasis, and is correlated with worse DFS.
Conclusions Tumor multiplicity has prognostic value and could be used to subclassify invasive breast cancer at early stages. Adjuvant chemotherapy would be necessary for multiple masses of T1–2 N0 M0, hormone-receptor-positive, and HER2-negative cancer.
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Alexandre Boulenger, Yanwen Luo, Chenhui Zhang, Chenyang Zhao, Yuanjing Gao, Mengsu Xiao, Qingli Zhu, Jie Tang Medical & Biological Engineering & Computing.2023; 61(2): 567. CrossRef - Multicentre prospective cohort study of unmet supportive care needs among patients with breast cancer throughout their cancer treatment trajectory in Penang: a PenBCNeeds Study protocol
Noorsuzana Mohd Shariff, Nizuwan Azman, Rohayu Hami, Noor Mastura Mohd Mujar, Mohammad Farris Iman Leong Bin Abdullah BMJ Open.2021; 11(3): e044746. CrossRef - The subgross morphology of breast carcinomas: a single-institution series of 2033 consecutive cases documented in large-format histology slides
Tibor Tot, Maria Gere, Syster Hofmeyer, Annette Bauer, Ulrika Pellas Virchows Archiv.2020; 476(3): 373. CrossRef - Editorial for “Synchronous Breast Cancer: Phenotypic Similarities on MRI”
Uma Sharma Journal of Magnetic Resonance Imaging.2020; 52(1): 309. CrossRef - Synchronous Multiple Breast Cancers—Do We Need to Reshape Staging?
Minodora Onisâi, Adrian Dumitru, Iuliana Iordan, Cătălin Aliuș, Oana Teodor, Adrian Alexandru, Daniela Gheorghiță, Iulian Antoniac, Adriana Nica, Alexandra-Ana Mihăilescu, Sebastian Grădinaru Medicina.2020; 56(5): 230. CrossRef - Molecular mechanism of triple‑negative breast cancer‑associated BRCA1 and the identification of signaling pathways
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- Secretory Carcinoma Arising in a Fibroadenoma: A Brief Case Report
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Sharon Lim, Min Keun Shim, Eun Yoon Cho, Soo Youn Cho
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J Pathol Transl Med. 2018;52(3):198-201. Published online October 4, 2017
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DOI: https://doi.org/10.4132/jptm.2017.08.01
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- Evaluation of Pathologic Complete Response in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: Experience in a Single Institution over a 10-Year Period
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Misun Choi, Yeon Hee Park, Jin Seok Ahn, Young-Hyuck Im, Seok Jin Nam, Soo Youn Cho, Eun Yoon Cho
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J Pathol Transl Med. 2017;51(1):69-78. Published online December 25, 2016
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DOI: https://doi.org/10.4132/jptm.2016.10.05
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- Background
Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) has been associated with favorable clinical outcome in breast cancer patients. However, the possibility that the prognostic significance of pCR differs among various definitions has not been established. Methods: We retrospectively evaluated the pathologic response after NAC in 353 breast cancer patients and compared the prognoses after applying the following different definitions of pCR: ypT0/is, ypT0, ypT0/is ypN0, and ypT0 ypN0. Results: pCR was significantly associated with improved distant disease-free survival (DDFS) regardless of the definition (ypT0/is, p = .002; ypT0, p = .008; ypT0/is ypN0, p < .001; ypT0 ypN0, p = .003). Presence of tumor deposits of any size in the lymph nodes (LNs; ypN ≥ 0(i+)) was associated with worse DDFS (ypT0 ypN0 vs ypT0 ypN ≥ 0(i+), p = .036 and ypT0/is ypN0 vs ypT0/is ypN ≥ 0(i+), p = .015), and presence of isolated tumor cells was associated with decreased overall survival (OS; ypT0/is ypN0 vs ypT0/is ypN0(i+), p = .013). Residual ductal carcinoma in situ regardless of LN status showed no significant difference in DDFS or OS (DDFS: ypT0 vs ypTis, p = .373 and ypT0 ypN0 vs ypTis ypN0, p = .462; OS: ypT0 vs ypTis, p = .441 and ypT0 ypN0 vs ypTis ypN0, p = .758). In subsequent analysis using ypT0/is ypN0, pCR was associated with improved DDFS and OS in triple-negative tumors (p < .001 and p = .003, respectively). Conclusions: Based on our study results, the prognosis and rate of pCR differ according to the definition of pCR and ypT0/is ypN0 might be considered a more preferable definition of pCR.
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Jung Wook Yang, Joungho Han, Hyun Woo Lee, Soo Youn Cho, Hong Kwan Kim
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J Pathol Transl Med. 2016;50(2):165-167. Published online October 8, 2015
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DOI: https://doi.org/10.4132/jptm.2015.07.15
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Yee Sing Lin, Christopher Cao, Wendy A. Cooper, Veronica Ka-Yan Cheung Pathology.2024; 56(3): 423. CrossRef - Pulmonary gangliocytic paraganglioma: An under-recognized mimic of carcinoid tumor
Julia R. Naso, Diping Wang, Arthur O. Romero, Timothy Leclair, Peter Smit, Jennifer M. Boland, Andrew L. Folpe, Melanie C. Bois Human Pathology.2024; 146: 23. CrossRef - Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas
Ozgur Mete, Sylvia L. Asa, Anthony J. Gill, Noriko Kimura, Ronald R. de Krijger, Arthur Tischler Endocrine Pathology.2022; 33(1): 90. CrossRef - The Rarest of Rare Thymic Lesions: A 10-Year Surgical Pathology Experience
Fiorella Calabrese, Francesco Fortarezza, Federica Pezzuto, Francesca Lunardi, Giovanni Comacchio, Marta Sbaraglia, Giulia Pasello, Giuseppe Marulli, Angelo Paolo Dei Tos, Federico Rea Cancers.2021; 13(16): 4056. CrossRef - Gangliocytic Paraganglioma of the Minor Papilla of the Duodenum
Hiroyuki Matsubayashi, Hirotoshi Ishiwatari, Toru Matsui, Shinya Fujie, Katsuhiko Uesaka, Teiichi Sugiura, Yukiyasu Okamura, Yusuke Yamamoto, Ryo Ashida, Takaaki Ito, Keiko Sasaki, Hiroyuki Ono Internal Medicine.2017; 56(9): 1029. CrossRef - Endoscopic resection of a periampullary gangliocytic paraganglioma of the duodenum: A case report
Christoph Paasch, Michael Hünerbein, Franz Theissig International Journal of Surgery Case Reports.2016; 29: 39. CrossRef - Duodenal Rare Neuroendocrine Tumor: Clinicopathological Characteristics of Patients with Gangliocytic Paraganglioma
Yoichiro Okubo, Tomoyuki Yokose, Osamu Motohashi, Yohei Miyagi, Emi Yoshioka, Masaki Suzuki, Kota Washimi, Kae Kawachi, Madoka Nito, Tetsuo Nemoto, Kazutoshi Shibuya, Yoichi Kameda Gastroenterology Research and Practice.2016; 2016: 1. CrossRef
- Biliary Granular Cell Tumor
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Changwon Jung, Ilyeong Heo, Sang Bum Kim, Sunhoo Park, Soo Youn Cho
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J Pathol Transl Med. 2015;49(1):89-91. Published online January 15, 2015
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DOI: https://doi.org/10.4132/jptm.2014.10.07
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- Granular cell tumor of the gallbladder: case report and review of the literature
Walid E Abdelrahim, Salwa O Mekki, Fatima M A Ali, Sarra Ahmed H Mukhtar, Kamal E Elssidig, Elthir A G Khalil, Omer Alfarog Journal of Surgical Case Reports.2019;[Epub] CrossRef - Malignant Granular Cell Tumor of the Bile Duct
Patrick L. Quinn, Eihab Abdelfatah, Mark A. Galan, Sushil K. Ahlawat, Ravi J. Chokshi ACG Case Reports Journal.2019; 6(8): e00193. CrossRef - Multifocal granular cell tumour of the biliary tree
Felip Vilardell, Marina Pardina, Jorge Juan Olsina, Xavier Matias-Guiu BMJ Case Reports.2018; 11(1): e226352. CrossRef - Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle
Isidro Machado, Julia Cruz, Javier Lavernia, Antonio Llombart-Bosch Virchows Archiv.2016; 468(5): 527. CrossRef
- Primary Myxoid Leiomyoma of the Liver
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Hee Seung Choi, Chang Won Jung, Soo Youn Cho, Sang Bum Kim, Sunhoo Park
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Korean J Pathol. 2014;48(1):54-57. Published online February 25, 2014
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DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.54
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7,604
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Herein, we report a case of primary myxoid leiomyoma of the liver. A 60-year-old woman complained of upper abdominal fullness. Computed tomography showed a solid tumor (8 cm) in the liver. The patient underwent right hepatectomy and histological findings from the resected specimen revealed scattered bland spindle cells in a background of exuberant myxoid material. The tumor cells were immunoreactive for smooth muscle actin and desmin. No other lesions were found elsewhere in the body. Thus, the tumor was diagnosed as a primary myxoid leiomyoma of the liver.
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- Hepatic Myxoid Leiomyoma: A Very Rare Tumor
João Fraga, Rui Caetano Oliveira, Luigi Terracciano, Mário Rui Silva, Maria Augusta Cipriano GE - Portuguese Journal of Gastroenterology.2020; 27(5): 352. CrossRef - A Firm Hepatic Mass Cannot Be Penetrated by US-Guided Needle Biopsy
Suk Hyun Jang, Sun Moon Kim, Jang Sihn Sohn, Ki Hyun Ryu, Hyung Bin Yuk Clinical Ultrasound.2016; 1(2): 126. CrossRef
- Fine Needle Aspiration Cytology of Parathyroid Lesions
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Ilyeong Heo, Sunhoo Park, Chang Won Jung, Jae Soo Koh, Seung-Sook Lee, Hyesil Seol, Hee Seung Choi, Soo Youn Cho
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Korean J Pathol. 2013;47(5):466-471. Published online October 25, 2013
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DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.466
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8,695
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- Background
There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria. MethodsWe selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011. ResultsMajor architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information. ConclusionsFNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.
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- Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort
Seyfettin Ilgan, Berna İmge Aydoğan, Özdeş Emer, Cüneyd Anıl, Alptekin Gürsoy, Mustafa Cesur, Banu Bilezikçi The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): 439. CrossRef - Fine needle aspiration biopsy of parathyroid; is it meaningful? A cytologic study of 81 cases with histological and clinical correlations
Elwira Bakuła‐Zalewska, Joanna Długosińska, Agata Stanek‐Widera, Piotr Góralski, Jacek Gałczyński, Agnieszka Żyłka, Monika Durzyńska, Marek Dedecjus Cytopathology.2024; 35(3): 362. CrossRef - Diagnosis of parathyroid incidentaloma detected on thyroid ultrasonography: the role of fine-needle aspiration cytology and washout parathyroid hormone measurements
Boeun Lee, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek Ultrasonography.2023; 42(1): 129. CrossRef - Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment
Shravan V. Gowrishankar, Rohan Bidaye, Tilak Das, Veronika Majcher, Brian Fish, Ruth Casey, Liam Masterson Head & Neck.2023; 45(3): 706. CrossRef - A stepwise approach to fine needle aspiration cytology of lymph nodes
Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee Journal of Pathology and Translational Medicine.2023; 57(4): 196. CrossRef - The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions
Uma Kundu, Qiong Gan, Deepak Donthi, Nour Sneige Diagnostics.2023; 13(14): 2400. CrossRef - Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature
S. Ivaniš, M. Jovanović, D. Dunđerović, G. Zorić, B. Odalović, N. Slijepčević, K. Taušanović, B. Rovčanin, M. Buzejić, D. Vučen, B. Stepanović, J. Ilić, M. Parezanović, M. Marinković, M. Stojanović, A. Tošković, I. Mojsić, V. Živaljević European Archives of Oto-Rhino-Laryngology.2023; 280(12): 5637. CrossRef - Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue
Ruhani Sardana, Rita Abi‐Raad, Adebowale J. Adeniran, Guoping Cai Cytopathology.2023; 34(6): 597. CrossRef - Parathyroid carcinoma: impact of preoperative diagnosis on the choice of surgical procedure
Yoshitaka Kawai, Yo Kishimoto, Hisanobu Tamaki, Takashi Fujiwara, Ryo Asato, Koji Ushiro, Shogo Shinohara, Shinpei Kada, Shinji Takebayashi, Tsuyoshi Kojima, Shuya Otsuki, Masakazu Miyazaki, Yohei Kumabe, Koichi Omori Endocrine Journal.2023; 70(10): 969. CrossRef - The Value of Preoperative and Intraoperative Ultrasound in the Localization of Intrathyroidal Parathyroid Adenomas
Wei Zhao, Ruigang Lu, Li Yin, Bojun Wei, Mulan Jin, Chun Zhang, Ruijun Guo, Xiuzhang Lv Journal of Investigative Surgery.2022; 35(4): 752. CrossRef - Cyto‐morphological features of parathyroid lesions: Fine‐needle aspiration cytology series from an endocrine tumor referral center
Sanna Steen, Martin Hysek, Jan Zedenius, Henrik Falhammar, Carl Christofer Juhlin Diagnostic Cytopathology.2022; 50(2): 75. CrossRef - Non‐secreting parathyroid carcinoma in a dog
Giovanni Tremolada, Paula Schaffer, Kathryne Pitt Veterinary Record Case Reports.2022;[Epub] CrossRef - Fine needle aspiration of an intrathyroidal parathyroid carcinoma mimicking a primary thyroid anaplastic carcinoma: A case report with review of the literature
Fatima Mir, Prih Rohra, Nfn Aakash, Karina Furlan, Ritu Ghai, Vijaya Reddy, Lin Cheng, Paolo Gattuso Diagnostic Cytopathology.2021;[Epub] CrossRef - Fine‐needle aspiration of parathyroid adenomas: Indications as a diagnostic approach
Ayana Suzuki, Mitsuyoshi Hirokawa, Risa Kanematsu, Aki Tanaka, Naoki Yamao, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi Diagnostic Cytopathology.2021; 49(1): 70. CrossRef - Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism
Wenjun Wu, Qi Zhou, Shihao Xu, Siqin An, Feixia Shen, Huanbin Li, Xiaohua Gong, Xiaojun Chen Endocrine.2021; 71(2): 476. CrossRef - Multimodal imaging of thyroid cancer
Katrin Brauckhoff, Martin Biermann Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 335. CrossRef - Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology
Hwa Jeong Ha, Eun Ju Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee Medicina.2020; 56(11): 558. CrossRef - Comparison of ultrasound-guided percutaneous microwave ablation and parathyroidectomy for primary hyperparathyroidism
Fangyi Liu, Xiaoling Yu, Zhoulu Liu, Zhi Qiao, Jianping Dou, Zhigang Cheng, Zhiyu Han, Jie Yu, Ping Liang International Journal of Hyperthermia.2019; 36(1): 834. CrossRef - Giant parathyroid adenoma: a case report and review of the literature
Mohamed S. Al-Hassan, Menatalla Mekhaimar, Walid El Ansari, Adham Darweesh, Abdelrahman Abdelaal Journal of Medical Case Reports.2019;[Epub] CrossRef - Water Clear Cell Parathyroid Adenoma: A Report of Two Cases
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Alfredo Campennì, Salvatore Giovinazzo, Salvatore Antonio Pignata, Francesca Di Mauro, Domenico Santoro, Lorenzo Curtò, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari Endocrine.2017; 56(1): 19. CrossRef - Fine needle cytology pre‐surgical differentiation of parathyroid neoplasms: Is it reliable?
A. Caleo, M. Vitale, L. Valvano, M. Siano, B. Angrisani, M. Forlenza, A. Massari, A. Puzziello, F. Salzano, P. Zeppa Cytopathology.2017; 28(4): 273. CrossRef - Identification of parathyroid tissue in thyroid fine‐needle aspiration: A combined approach using cytology, immunohistochemical, and molecular methods
Robert P. Domingo, Lorna L. Ogden, Laura C. Been, Giulia C. Kennedy, S. Thomas Traweek Diagnostic Cytopathology.2017; 45(6): 526. CrossRef - Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid
Simon Sung, Anjali Saqi, Elizabeth M. Margolskee, John P. Crapanzano CytoJournal.2017; 14: 10. CrossRef - Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung Pathology - Research and Practice.2016; 212(1): 44. CrossRef - Parathyroid lesions: Difficult diagnosis on cytology
Charu Agarwal, Manju Kaushal Diagnostic Cytopathology.2016; 44(8): 704. CrossRef - Intrathyroidal parathyroid adenoma: Diagnostic pitfalls on fine‐needle aspiration: Two case reports and literature review
Chang Shi, Hongwei Guan, Wenjing Qi, Jialin Ji, Jialing Wu, Feng Yan, Huali Wang Diagnostic Cytopathology.2016; 44(11): 921. CrossRef - Diagnostic value of GATA-3 in cytological identification of parathyroid tissues
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi Endocrine Journal.2016; 63(7): 621. CrossRef - PARATHYROID CYTOLOGY: A DIAGNOSTIC DILEMMA
Naval Kishore Bajaj, Shrinivas Somalwar, Akhtar Mohammad, Ezhil Arasi Nagamuthu Journal of Evidence Based Medicine and Healthcare.2016; 3(71): 3849. CrossRef - Fine-Needle Aspiration Cytology of Parathyroid Lesions
Teklu Legesse, Paul N. Staats Pathology Case Reviews.2015; 20(5): 227. CrossRef - A nonfunctioning parathyroid carcinoma misdiagnosed as a follicular thyroid nodule
Filomena Cetani, Gianluca Frustaci, Liborio Torregrossa, Silvia Magno, Fulvio Basolo, Alberto Campomori, Paolo Miccoli, Claudio Marcocci World Journal of Surgical Oncology.2015;[Epub] CrossRef
- Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung
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Hee Seung Choi, Hyesil Seol, Il Yeong Heo, Chang Won Jung, Soo Youn Cho, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee
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Korean J Pathol. 2012;46(6):576-582. Published online December 26, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.576
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6,753
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Abstract
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- Background
Pleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC. MethodsWe reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks. ResultsThe tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin. ConclusionsPC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.
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- Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations
Atreyee Basu, Andre L. Moreira, Anthony Simms, Tamar C. Brandler Diagnostic Cytopathology.2019; 47(8): 813. CrossRef - Cytological Evaluation of Pleomorphic Carcinoma of the Lung
Kevin Kuan, Samer N. Khader, Siba El Hussein Diagnostic Cytopathology.2019; 47(9): 961. CrossRef - Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology
Yusuke Ebisu, Mitsuaki Ishida, Tomohito Saito, Tomohiro Murakawa, Yoshiko Uemura, Koji Tsuta Oncology Letters.2017;[Epub] CrossRef - Pulmonary Pleomorphic Carcinoma Detected as a Result of Pneumothorax and the Subsequent Occurrence of Multiple Cystic Metastases
Hideaki Yamakawa, Masahiro Yoshida, Masami Yabe, Yuri Baba, Emiri Baba, Hiroaki Katagi, Takeo Ishikawa, Masamichi Takagi, Takeo Nakada, Tadashi Akiba, Kazuyoshi Kuwano Case Reports in Medicine.2014; 2014: 1. CrossRef - Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia
PENG-FEI LI, CHENG-HSIANG LO, SHAN-HAN YANG, PING-YING CHUNG, CHING-LIANG HO Oncology Letters.2014; 7(2): 452. CrossRef
- Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript
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Han Suk Ryu, Ilyeong Heo, Jae Soo Koh, Sung-Ho Jin, Hye Jin Kang, Soo Youn Cho
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Korean J Pathol. 2012;46(2):187-191. Published online April 25, 2012
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DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.187
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5,947
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Abstract
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Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.
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- A case of primary mesenteric synovial sarcoma: a challenging presentation
Nihed Abdessayed, Malek Barka, Samiha Mabrouk, Zeineb Nfikha, Zeineb Maatoug, Yosra Fejji, Mohamed Salah Jarrar, Sabri Youssef, Moncef Mokni Surgical Case Reports.2023;[Epub] CrossRef - Giant solitary fibrous tumor of the pelvis: A case report and review of literature
Gerardo Palmieri, Carmine Grassi, Luigi Conti, Filippo Banchini, Maria Diletta Daccò, Gaetano M. Cattaneo, Patrizio Capelli International Journal of Surgery Case Reports.2020; 77: S52. CrossRef - Tumeur neuroectodermique gastro-intestinale (GNET) : à propos d’un cas de tumeur du grêle avec métastases hépatiques
Thibault Kervarrec, Claire Lecointre, Rémy Kerdraon, Guido Bens, Arnaud Piquard, Patrick Michenet Annales de Pathologie.2015; 35(6): 506. CrossRef
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